Summary
A dibenzofuran-based β-turn mimic has been incorporated in the B12–29 fragment of the B1 domain of streptococcal protein G. This amino acid sequence adopts a β-hairpin structure in the complete B1 domain (B12–56). The modified peptide was studied by CD and NMR spectroscopy and its solution behavior was compared with the conformation adopted by the same sequence in the modified B1 domain.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Tsang, K.Y., Diaz, H., Graciani, N. and Kelly, J.W., J. Am. Chem. Soc., 116 (1994) 3988
Jean, F., Buisine, E., Melnyk, O., Hugues, M., Drobecq, H., Lippens, G. and Tartar, A., submitted to J. Am. Chem. Soc.
Gronenborn, A.M., Filpula, D.R., Essig, N.Z., Achari, A., Whitlow, M., Wingfield, P.T. and Clore, G.M., Science, 253 (1991) 657.
Bjorck, L. and Kronvall, G., J. Immunol., 133 (1984) 969.
Blanco, F.J. and Serrano, L., Eur. J. Biochem., 230 (1995) 634.
Blanco, F.J., Jimenez, M.A., Pineda, A., Rico, M., Santoro, J. and Nieto, J.L., Biochemistry, 33 (1994) 6004.
Odaert, B., Jean, F., Boutillon, C., Buisine, E., Melnyk, O., Tartar, A. and Lippens, G., in preparation.
Neri, D., Billeter, M., Wider, G. and Wüthrich, K., Science, 257 (1992) 1559.
Minor, D.L. and Kim, P.S., Nature, 380 (1996) 730.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Melnyk, O., Boutillon, C., Draffan, L. et al. Incorporation of a β-turn mimic in the N-terminal fragment of the B1 domain of streptococcal protein G. Lett Pept Sci 5, 147–150 (1998). https://doi.org/10.1007/BF02443458
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02443458