Application of finite-element analysis with optimisation to assess thein vivo non-linear myocardial material properties using echocardiographic imaging
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An application of finite-element analysis with an optimisation technique to assess the myocardial material properties in diastasisin vivo is described. Using the data collected from an animal model, the three-dimensional geometry of the left ventricular chamber, at several times in diastole, was reconstructed. From the measurement of the ventricular chamber pressure during image acquisition, finite-element analysis was performed to predict the expansion during diastasis. Initially, by restricting the motion of the epicardial nodes and computing the reaction forces, an ‘equivalent pericardial pressure’ was determined and applied in subsequent analysis. The duration of diastasis was divided into three or four intervals and the analysis was performed at each interval to assess the material properties of the myocardium. Using such a step-wise linear approach, the non-linear material properties of the myocardium during passive expansion was determined. Our results demonstrated that the computed ‘equivalent pericardial pressure’ increased with and was smaller than the corresponding left ventricularchamber pressure. The passive myocardium exhibited a linear tangent modulus against chamber pressure relationship which is equivalent to an exponential stress/strain relationship, similar to those suggested byin vitro studies.
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- Application of finite-element analysis with optimisation to assess thein vivo non-linear myocardial material properties using echocardiographic imaging
Medical and Biological Engineering and Computing
Volume 31, Issue 5 , pp 459-467
- Cover Date
- Print ISSN
- Online ISSN
- Kluwer Academic Publishers
- Additional Links
- Exponential stress/strain relationship
- Finite-element analysis
- Left ventricular expansion
- Passive myocardium
- Tangential elastic modulus
- Three-dimensional geometry
- Industry Sectors
- Author Affiliations
- 1. Department of Biomedical and Mechanical Engineering and Iowa Institute of Bioemedical Engineering, College of Engineering, University of lowa, 1204 EB, 52242, lowa City, IA, USA
- 2. Department of Internal Medicine, University of lowa, 52242, lowa City, IA, USA
- 3. Department of Surgery, Northwestern University School of Medicine, 582 Wesley, 250 East Superior, 60611, Chicago, IL, USA