Psychopharmacology

, Volume 93, Issue 1, pp 133–135

Activation of forebrain dopamine systems by phencyclidine and footshock stress: evidence for distinct mechanisms

  • M. B. BowersJr
  • M. J. Bannon
  • F. J. HoffmanJr
Rapid Communication

DOI: 10.1007/BF02439600

Cite this article as:
Bowers, M.B., Bannon, M.J. & Hoffman, F.J. Psychopharmacology (1987) 93: 133. doi:10.1007/BF02439600

Abstract

Phencyclidine combined with footshock stress produced a greater increase in the homovanillic acid content of prefrontal cortex than either phencyclidine or footshock alone. Phencyclidine decreased both substance P and substance K in the ventral tegmental area. The results suggest that phencyclidine and footshock activate forebrain dopaminergic systems in part by separate mechanisms.

Key words

Phencyclidine Footshock stress Prefrontal cortex Substance P Substance K Ventral tegmental area Homovanillic acid 

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • M. B. BowersJr
    • 1
  • M. J. Bannon
    • 1
  • F. J. HoffmanJr
    • 1
  1. 1.Departments of Psychiatry and Pharmacology, The Abraham Ribicoff Research Facilities, Connecticut Mental Health CenterYale University School of MedicineUSA
  2. 2.New HavenUSA