Activation of forebrain dopamine systems by phencyclidine and footshock stress: evidence for distinct mechanisms
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- Bowers, M.B., Bannon, M.J. & Hoffman, F.J. Psychopharmacology (1987) 93: 133. doi:10.1007/BF02439600
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Phencyclidine combined with footshock stress produced a greater increase in the homovanillic acid content of prefrontal cortex than either phencyclidine or footshock alone. Phencyclidine decreased both substance P and substance K in the ventral tegmental area. The results suggest that phencyclidine and footshock activate forebrain dopaminergic systems in part by separate mechanisms.