, Volume 43, Issue 5, pp 877-879

CEN14 sequences cause slower proliferation, reduced cell size and asporogeny inSaccharomyces cerevisiae

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The introduction ofCEN14-based plasmids into haploid strains ofSaccharomyces cerevisiae resulted in reduced proliferation rates and significantly smaller (20%) cell size than in untransformed control cells. This could be useful to those yeast biotechnology processes that require high levels of gene expression but little or no yeast growth and proliferation. In diploids similar plasmids caused asporogeny, which was possibly a consequence of the reduced cell size.