Biology and Philosophy

, Volume 6, Issue 2, pp 135–154

Epigenetic landscaping: Waddington's use of cell fate bifurcation diagrams

Authors

  • Scott F. Gilbert
    • Department of BiologySwarthmore College
Article

DOI: 10.1007/BF02426835

Cite this article as:
Gilbert, S.F. Biol Philos (1991) 6: 135. doi:10.1007/BF02426835

Abstract

From the 1930s through the 1970s, C. H. Waddington attempted to reunite genetics, embryology, and evolution. One of the means to effect this synthesis was his model of the epigenetic landscape. This image originally recast genetic data in terms of embryological diagrams and was used to show the identity of genes and inducers and to suggest the similarities between embryological and genetic approaches to development. Later, the image became more complex and integrated gene activity and mutations. These revised epigenetic landscapes presented an image of how mutations could alter developmental pathways to yield larger phenotypic changes. These diagrams became less important as the operon became used to model differential gene regulation.

Key Words

Epigenetic landscapesynthesis of evolutiongenetics and developmentWaddington
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Copyright information

© Kluwer Academic Publishers 1991