Journal of Autism and Developmental Disorders

, Volume 14, Issue 2, pp 197–204

Familial autism and the fragile-X chromosome

  • Gerald J. August
  • Lillian H. Lockhart
Article

DOI: 10.1007/BF02409662

Cite this article as:
August, G.J. & Lockhart, L.H. J Autism Dev Disord (1984) 14: 197. doi:10.1007/BF02409662

Abstract

This report presents two male siblings in whom the diagnosis of infantile autism was found in association with a fragile site on the X chromosome. In addition to their marked autistic characteristics, formal examinations indicated that both boys were severely mentally retarded and had several physical features commonly observed in association with the fragile-X syndrome. The mother of these two siblings also gave birth to identical twin boys, who were developmentally delayed and showed several autistic features prior to their untimely death in a house fire. The possible role of the fragile-X chromosome as an etiological factor in families where there is a clustering of autism and related developmental disturbances is discussed.

Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • Gerald J. August
    • 1
  • Lillian H. Lockhart
    • 1
  1. 1.Department of Psychiatry and Behavioral SciencesUniversity of Texas Medical BranchGalveston