, Volume 33, Issue 1, pp 673-676

1,25-Dihydroxyvitamin D3 and the regulation of macrophage function

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Vitamin D3 deficient (D) mice show a depressed inflammatory response and both inflammatory peritoneal macrophages and bone marrow polymorphonuclear leukocytes of D mice exhibit a decreased spontaneous migration under agarose. The impaired phagocytic response of peritoneal macrophages from D mice can be corrected by incubation with 1,25-dihydroxyvitamin D3 and is not affected by interaction with other vitamin D3 metabolites. Transfer of mice from the D to the D+ state results in correction of both the inflammatory and the phagocytic response. Intactness of phagocyte function is thus directly dependent on vitamin D3 metabolism.