Calcified Tissue International

, Volume 33, Issue 1, pp 673–676

1,25-Dihydroxyvitamin D3 and the regulation of macrophage function

  • Z. Bar-Shavit
  • D. Noff
  • S. Edelstein
  • M. Meyer
  • S. Shibolet
  • R. Goldman
Rapid Communications

DOI: 10.1007/BF02409507

Cite this article as:
Bar-Shavit, Z., Noff, D., Edelstein, S. et al. Calcif Tissue Int (1981) 33: 673. doi:10.1007/BF02409507

Summary

Vitamin D3 deficient (D) mice show a depressed inflammatory response and both inflammatory peritoneal macrophages and bone marrow polymorphonuclear leukocytes of D mice exhibit a decreased spontaneous migration under agarose. The impaired phagocytic response of peritoneal macrophages from D mice can be corrected by incubation with 1,25-dihydroxyvitamin D3 and is not affected by interaction with other vitamin D3 metabolites. Transfer of mice from the D to the D+ state results in correction of both the inflammatory and the phagocytic response. Intactness of phagocyte function is thus directly dependent on vitamin D3 metabolism.

Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • Z. Bar-Shavit
    • 1
  • D. Noff
    • 2
  • S. Edelstein
    • 2
  • M. Meyer
    • 3
  • S. Shibolet
    • 3
  • R. Goldman
    • 1
  1. 1.Department of Membrane ResearchThe Weizmann Institute of ScienceRehovot
  2. 2.Department of BiochemistryThe Weizmann Institute of ScienceRehovot
  3. 3.Department of Internal Medicine “D”Ichilov HospitalTel AvivIsrael