, Volume 14, Issue 1, pp 105-111

A comparison of autistic syndromes with and without associated neurological problems

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The findings show that autistic syndromes with and without associated neurological deficits are remarkably similar in terms of severity and type of autistic symptoms, IQ, and sex distribution. Children with an associated neurological disorder tended to have had autistic features from birth, but this may have been an artifact resulting from the closer clinical observation that many would have received because of their medical problems. Findings from related studies have also shown that autistic syndromes with and without neurological deficits do not differ with respect to urinary homovanillic acid levels (Garreau et al., 1980), dihydroxy-phenylacetic acid levels (Landgrebe & Landgrebe, 1976), auditory evoked potentials (Martineau, Garreau, Barthelemy, Callaway, & LeLord, 1981) or response to vitamin B6 administration (LeLord et al., 1981; Martineau et al., 1981).

This research was supported by CNRS (ERA N-697) “Biology and Neuropsychiatry,” INSERM 650.34 and Social Security 1982. We wish to thank Mrs. Barre, Mrs. Lardeux, and Mrs. Crespin for their technical work.