, Volume 10, Issue 2, pp 129-137

Ineffectiveness of imipramine in children who fail to respond to methylphenidate

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Abstract

Ten hyperactive children who had failed to respond to methylphenidate were treated with imipramine in a placebo-controlled, crossover design. No significant drug effects were obtained either on parent and teacher ratings of the child's behavior or on the child's performance in a laboratory measure of sustained attention. Findings suggest that imipramine has limited clinical usefulness in the treatment of hyperactive children who fail to respond to methylphenidate.

This research was supported in part by a grant to Dr. Winsberg from Ciba-Geigy Pharmaceuticals. The authors gratefully acknowledge Dr. Jeffrey Sverd and Dr. Andrew B. Bremness for their assistance in providing drug management.