Neurosurgical Review

, Volume 21, Issue 2, pp 117–120

The effect of duration of compression on lipid peroxidation after experimental spinal cord injury

  • Mehmet Yaşar Kaynar
  • Murat Hanci
  • Ali Kafadar
  • Koray Gümüştaş
  • Ahmed Belce
  • Nejat Çiplak
Article

DOI: 10.1007/BF02389316

Cite this article as:
Kaynar, M.Y., Hanci, M., Kafadar, A. et al. Neurosurg. Rev. (1998) 21: 117. doi:10.1007/BF02389316

Abstract

The present study was performed to evaluate the effect of duration of acute spinal cord compression on tissue lipid peroxidation in rats. A clip compression method (1) was used to produce acute spinal cord injury. Rats were divided into 3 groups, each consisting of 10. At 1 hour after trauma all rats were sacrificed, and MDA content of the injured spinal cord segment was measured. The tissue MDA contents were 3.922 μmolMDA/gww in group 1 (control), 10.192 μmol MDA/gww in group 2 (30 seconds compression), and 12.147 μmolMDA/gww in group 3 (60 seconds compression). These results demonstrate that the length of duration of compression significantly enhances lipid peroxidation. Our study supported the view that persisting compression may cause progression of secondary mechanisms which may irreversibly eliminate any potential for recovery.

Keywords

Experimental spinal cord injury lipid peroxidation 

Copyright information

© Walter de Gruyter GmbH & Co 1998

Authors and Affiliations

  • Mehmet Yaşar Kaynar
    • 1
  • Murat Hanci
    • 1
  • Ali Kafadar
    • 1
  • Koray Gümüştaş
    • 2
  • Ahmed Belce
    • 2
  • Nejat Çiplak
    • 1
  1. 1.Department of NeurosurgeryIstanbul University Cerrahpaşa Medical FacultyAksaray IstanbulTurkey
  2. 2.Department of BiochemistryIstanbul University Cerrahpaşa Medical FacultyAksaray IstanbulTurkey