Journal of Gastroenterology

, Volume 31, Issue 6, pp 818–822

Consecutive evaluation of immunoglobulin M and G antibodies against hepatitis E virus

  • Wel-Min Ke
  • De Tan
  • Jian-Guo Li
  • Satoru Izumi
  • Yoshitake Shinji
  • Hak Hotta
  • Ji-Lu Yao
Liver, Pancreas, and Biliary Tract

DOI: 10.1007/BF02358608

Cite this article as:
Ke, WM., Tan, D., Li, JG. et al. J Gastroenterol (1996) 31: 818. doi:10.1007/BF02358608

Abstract

Hepatitis E virus (HEV) infection is sporadic in the Guangzhou city southern China. However, the evaluation of antibodies to HEV during consecutive time periods after infection has not been reported. We utilized enzyme immunosorbent assay (ELISA) to detect IgM and IgG anti-HEV in consecutive serum specimens from patients with acute hepatitis E and compared that data with detection rates of IgM and IgG anti-HAV in patients with acute hepatitis A. IgM anti-HEV can be detected as early as 4 days after onset of disease symptoms in some patients. The detection rate of IgM anti-HEV is significantly higher in specimens collected within 4 weeks (95%) of onset than in those specimens collected 4 to 18 weeks after onset (67.6%) (P<0.005). IgM anti-HEV had a similar pattern to IgM anti-HAV and can be used as a marker of acute HEV infection. In contrast with IgG anti-HAV, 56.8% of the specimens did not contain detectable levels of IgG anti-HEV (P<0.005). One should be cautioned against making a diagnosis of HEV infection solely by the currently available assays for IgG anti-HEV. In conclusion, IgM anti-HEV can be used as a reliable and sensitive marker for recent HEV infection, but serum specimens should be collected within 4 weeks after onset of symptoms to avoid false-negative results. In contrast, we should be aware of the failure to develop IgG anti-HEV in some patients. These patients carry the risk of reinfection.

Key words

hepatitis E virusIgM and IgG anti-HEVELISA

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • Wel-Min Ke
    • 1
  • De Tan
    • 2
  • Jian-Guo Li
    • 1
  • Satoru Izumi
    • 3
  • Yoshitake Shinji
    • 4
  • Hak Hotta
    • 5
  • Ji-Lu Yao
    • 1
  1. 1.Department of Infectious DiseasesThird affiliated Hospitol of Sun Yat-Sen University of Medical SciencesGuangzhouP.R. China
  2. 2.Department of Transfusion Medicine, Clinical CenterNational Institutes of HealthBethesdaUSA
  3. 3.Health Development SectionSumitomo BankOsakaJapan
  4. 4.Department of Internal MedicineHyogo Prefectural Nishinomiya HospitalHyogoJapan
  5. 5.Department of MicrobiologyKobe University School of MedicineHyogoJapan