Article

Medical and Biological Engineering and Computing

, Volume 41, Issue 3, pp 324-329

Combined near-infrared spectroscopy and multifrequency bio-impedance investigation of skin alterations in diabetes patients based on multivariate analyses

  • J. NyströmAffiliated withDepartment of Chemistry, Ume⇘ UniversityCenter for Biomedical Engineering and Physics, Ume⇘ University
  • , B. Lindholm-SethsonAffiliated withDepartment of Chemistry, Ume⇘ UniversityCenter for Biomedical Engineering and Physics, Ume⇘ University Email author 
  • , L. StenbergAffiliated withDepartment of Chemistry, Ume⇘ University
  • , S. OllmarAffiliated withDivision of Medical Engineering, Karolinska Institutet
  • , J. W. ErikssonAffiliated withDepartment of Medicine, Ume⇘ University Hospital
  • , P. GeladiAffiliated withThe Unit of Biomass Technology & Chemistry, Swedish University of Agricultural Sciences

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Abstract

A group of 34 diabetic men, with different degrees of diabetes complications, including skin changes, were studied by near-infrared (NIR) spectroscopy and total body multi-frequency bio-impedance analyses (MFBIA-body). Skin reflectance spectra were measured with a fibre-optic probe in four locations (sites): hand, arm, leg and foot. As control subjects, a group of 23 healthy males were also measured. A combined multivariate analysis of the two types of spectrum was performed. It was concluded that the NIR method has the potential to detect diabetes-related skin conditions and also that the combination of the two techniques provides a higher potential for classification and discrimination of the skin conditions, with correct classification increasing from 63% to 85%.

Keywords

NIR Total body bio-impedance Fibre-optic probe PCA Skin changes Diabetes