Rapid Communications

Diabetologia

, Volume 31, Issue 6, pp 400-402

First online:

Prevention of lymphocytic thyroiditis and insulitis in diabetes-prone BB rats by the depletion of macrophages

  • K. U. LeeAffiliated withDivision of Virology, Department of Microbiology and Infectious Diseases, and Laboratory of Viral and Immunopathogenesis of Diabetes, Julia McFarlane Diabetes Research Centre, The University of Calgary
  • , C. Y. PakAffiliated withDivision of Virology, Department of Microbiology and Infectious Diseases, and Laboratory of Viral and Immunopathogenesis of Diabetes, Julia McFarlane Diabetes Research Centre, The University of Calgary
  • , K. AmanoAffiliated withDivision of Virology, Department of Microbiology and Infectious Diseases, and Laboratory of Viral and Immunopathogenesis of Diabetes, Julia McFarlane Diabetes Research Centre, The University of Calgary
  • , J. W. YoonAffiliated withDivision of Virology, Department of Microbiology and Infectious Diseases, and Laboratory of Viral and Immunopathogenesis of Diabetes, Julia McFarlane Diabetes Research Centre, The University of Calgary

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Summary

Diabetes-prone biobreeding (BB) rats often develop lymphocytic thyroiditis. Intraperitoneal administration of silica to young BB rats (40-days-old) nearly completely prevented the development of lymphocytic thyroiditis as well as insulitis. Since silica is known to be toxic to macrophages, these data suggest that the presentation of autoantigen(s) on the specific target cells such as thyroid and pancreatic B cells by antigen-presenting cells (e.g., macrophages) would be the initial step in the development of organ-specific autoimmune diseases in diabetes-prone BB rats.

Key words

Autoimmunity BB rats Type 1 (insulin-dependent) diabetes lymphocytic thyroiditis insulitis silica macrophage antigen-presenting cell