European Journal of Clinical Pharmacology

, Volume 38, Issue 5, pp 461–463

Antagonism by domperidone of the ocular hypotensive effect of pergolide

  • M. R. Al-Sereiti
  • R. F. P. Quik
  • A. Hedges
  • P. Turner
Originals

DOI: 10.1007/BF02336684

Cite this article as:
Al-Sereiti, M.R., Quik, R.F.P., Hedges, A. et al. Eur J Clin Pharmacol (1990) 38: 461. doi:10.1007/BF02336684

Summary

1 The effect of pre-dosing with 15 mg domperidone, a relatively selective dopamine 2-receptor antagonist, on the ocular hypotensive action of a single oral dose of 25 μg pergolide, a dopamine 2-receptor agonist, was studied in 9 normal human volunteers, using a non-invasive method.

2 Compared with domperidone followed after 1 h by placebo, placebo followed after 1 h by pergolide had an ocular hypotensive effect in both eyes. Domperidone followed after 1 h by pergolide had no effect on intraocular pressure in both eyes.

2 The results of this study showed that domperidone inhibited the ocular hypotensive action of pergolide, suggesting that pergolide reduces introcular pressure by the stimulation of the peripheral dopamine 2-receptors.

Key words

domperidone pergolide dopaminergic agonists intraocular pressure non-contact tonometer drug interaction 

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • M. R. Al-Sereiti
    • 1
  • R. F. P. Quik
    • 2
  • A. Hedges
    • 1
  • P. Turner
    • 1
  1. 1.Department of Clinical PharmacologySt. Bartholomew's HospitalLondon
  2. 2.Lilly Research Centre Ltd.Windlesham