Originals

Chromatographia

, Volume 28, Issue 3, pp 126-128

First online:

Preparative isolation of (+)-beta-eudesmol fromAmyris balsamifera

  • T. A. van BeekAffiliated withDepartment of Organic Chemistry, Phytochemical Section, Agricultural University
  • , R. KleisAffiliated withDepartment of Organic Chemistry, Phytochemical Section, Agricultural University
  • , G. P. LelyveldAffiliated withDepartment of Organic Chemistry, Phytochemical Section, Agricultural University
  • , AE. de GrootAffiliated withDepartment of Organic Chemistry, Phytochemical Section, Agricultural University

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Summary

Optically pure (+)-beta-eudesmol is a possible starting material for the synthesis of several termite defense compounds. A two step procedure for the isolation of gram quantities of (+)-beta-eudesmol from commercially availableAmyris balsamifera oil (syn. West Indian sandalwood oil), containing 8% beta-eudesmol, was developed. Step one consisted of an efficient vacuum distillation of the total oil. Step two was a medium pressure LC separation with an AgNO3 impregnated silica gel stationary phase. Several other separation procedures failed due to the presence of many closely related sesquiterpene alcohols (75% of the oil).

Key Words

Column liquid chromatography Preparative isolation (+)-Beta-eudesmol Amyris balsamifera