Preparative isolation of (+)-beta-eudesmol fromAmyris balsamifera
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- van Beek, T.A., Kleis, R., Lelyveld, G.P. et al. Chromatographia (1989) 28: 126. doi:10.1007/BF02319632
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Optically pure (+)-beta-eudesmol is a possible starting material for the synthesis of several termite defense compounds. A two step procedure for the isolation of gram quantities of (+)-beta-eudesmol from commercially availableAmyris balsamifera oil (syn. West Indian sandalwood oil), containing 8% beta-eudesmol, was developed. Step one consisted of an efficient vacuum distillation of the total oil. Step two was a medium pressure LC separation with an AgNO3 impregnated silica gel stationary phase. Several other separation procedures failed due to the presence of many closely related sesquiterpene alcohols (75% of the oil).