Clinical Autonomic Research

, Volume 8, Issue 6, pp 359–362

Consensus statement on the diagnosis of multiple system atrophy

  • Sid Gilman
  • Phillip Low
  • Niall Quinn
  • Alberto Albanese
  • Yoav Ben-Shlomo
  • Clare Fowler
  • Horacio Kaufmann
  • Thomas Klockgether
  • Anthony Lang
  • Peter Lantos
  • Irene Litvan
  • Christopher Mathias
  • Eugene Oliver
  • David Robertson
  • Irwin Schatz
  • Gregor Wenning
Consensus Report

DOI: 10.1007/BF02309628

Cite this article as:
Gilman, S., Low, P., Quinn, N. et al. Clinical Autonomic Research (1998) 8: 359. doi:10.1007/BF02309628

Abstract

We report the results of a consensus conference on the diagnosis of multiple system atrophy (MSA). We describe the clinical features of the disease, which include four domains: autonomic failure/urinary dysfunction, parkinsonism and cerebellar ataxia, and corticospinal dysfunction. We set criteria to define the relative importance of these features. The diagnosis of possible MSA requires one criterion plus two features from separate domains. The diagnosis of probable MSA requires the criterion for autonomic failure/urinary dysfunction plus poor levodopa responsive parkinsonism or cerebellar ataxia. The diagnosis of definite MSA requires pathological confirmation.

Keywords

multiple system atrophy parkinsonism cerebellar ataxia autonomic insufficiency urinary dysfunction glial cytoplasmic inclusions 

Copyright information

© Lippincott Williams & Wilkins 1998

Authors and Affiliations

  • Sid Gilman
    • 1
  • Phillip Low
    • 1
  • Niall Quinn
    • 1
  • Alberto Albanese
    • 1
  • Yoav Ben-Shlomo
    • 1
  • Clare Fowler
    • 1
  • Horacio Kaufmann
    • 1
  • Thomas Klockgether
    • 1
  • Anthony Lang
    • 1
  • Peter Lantos
    • 1
  • Irene Litvan
    • 1
  • Christopher Mathias
    • 1
  • Eugene Oliver
    • 1
  • David Robertson
    • 1
  • Irwin Schatz
    • 1
  • Gregor Wenning
    • 1
  1. 1.Department of NeurologyUniversity of Michigan Medical CenterAnn ArborUSA