Heat shock protein 27 overexpression in breast cancer lymph node metastasis
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Background: Heat shock protein 27 (hsp-27) is overexpressed in ∼67% pure ductal carcinoma in situ (DCIS), in ∼50% DCIS associated with invasive ductal carcinoma (IDC), and in ∼25% IDC alone. If this decrease in hsp-27 expression has a role in the progression of malignancy in IDC, we postulate a further reduction in expression in nodal metastasis.
Methods: To test this hypothesis, we evaluated the distribution of hsp-27 in primary IDC and in synchronous regional lymph node metastasis within the same patient by immunohistochemistry.
Results: Nine of 30 primary IDCs (30%) and 22 of 30 lymph node metastases (73%) overexpressed hsp-27. Contrary to our hypothesis, of 21 IDCs with no or low hsp-27 expression, 13 (62%) had overexpression of this protein within nodal metastasis.
Conclusions: hsp-27 appears to confer cytoprotection for metastatic cells, which may help explain why hsp-27 overexpression is associated with reduced disease-free survival in breast carcinomas.
- Ciocca DR, Adams DJ, Edwards DP, Bjercke RJ, McGuire WL. Distribution of an estrogen-induced protein with a molecular weight of 24,000 in normal and malignant human tissues and cells.Cancer Res 1983;43:1204–10.
- Tandon AK, Clark GM, Chamness GC, et al. Clinical significance of heat-shock/stress-response proteins in breast cancer.Breast Cancer Res Treat 1990;16:146.
- Chamness GC, Ruiz A, Fulcher L, Clark G, Fuqua SAW, McGuire WL. Stress responsive protein srp27 predicts recurrence in node-negative breast cancers.Breast Cancer Res Treat 1988;12:130.
- Storm FK, Gilchrist KW, Warner TFCS, Mahvi DM. Distribution of hsp-27 and HER-2/neu in in situ and invasive ductal breast cancer.Ann Surg Oncol 1995;2:43–8. CrossRef
- Adams DJ, Hajj H, Edwards DP, Bjercke RJ, McGuire WL. Detection of a Mw 24,000 estrogen-regulated protein in human breast cancer by monoclonal antibodies.Cancer Res 1983;43:4297–301.
- Thor A, Benz C, More D, et al. Stress response protein (srp-27) determination in primary human breast carcinomas: Clinical, histologic, and prognostic correlations.J Natl Cancer Inst 1991;83:170–8.
- Tetu B, Lacasse B, Bouchard H-L, Lagace R, Huot J, Landry J. Prognostic significance of hsp-27 expression in malignant fibrous histiocytoma: a clinicopathological and immunohistochemical study.Cancer Res 1992;52:2325–8.
- Carper SW, Duffy JJ, Gerner EW. Heat shock proteins in thermotolerance and other cellular processes.Cancer Res 1987;47:5249–55.
- Ciocca DR, Steffi O, Chamness GC, McGuire WL, Fuqua SAW. Biological and clinical implications of heat shock protein 27,000 (hsp27): review.J Natl Cancer Inst 1993;85:1558–70.
- Hickey E, Brandon SE, Potter R, Stein G, Stein J, Weber LA. Sequence and organization of genes encoding the human 27 kDa heat shock protein.Nucleic Acids Res 1986;14:4127–45.
- Carper SW, Rocheleau TA, Storm FK. cDNA sequence of a human heat shock protein hsp-27.Nucleic Acids Res 1990;18:6457.
- Rothman JE. Polypeptide chain binding proteins: catalysts of protein folding and related processes in cells.Cell 1989;59:591–601. CrossRef
- Storm FK, Mahvi DM, Gilchrist KW. Hsp-27 is not expressed and has no prognostic significance in rectal adenocarcinoma.Reg Cancer Treat 1993;3:146–8.
- Storm FK, Mahvi DM, Gilchrist KW. Hsp-27 has no diagnostic or prognostic significance in prostate or bladder cancer.Urology 1993;42:379–82. CrossRef
- Allred DC, Clark GM, Molina R, et al. Overexpression of HER-2/neu and its relationship with other prognostic factors change during the progression of in situ to invasive breast cancer.Hum Pathol 1992;23:974–9. CrossRef
- Heat shock protein 27 overexpression in breast cancer lymph node metastasis
Annals of Surgical Oncology
Volume 3, Issue 6 , pp 570-573
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- Heat shock protein 27
- Breast cancer
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- Author Affiliations
- 1. From the Department of Surgery, Section of Oncology, University of Wisconsin School of Medicine and the Comprehensive Cancer Center, Madison, Wisconsin, USA
- 3. Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and the Comprehensive Cancer Center, Madison, Wisconsin, USA