Annals of Surgical Oncology

, Volume 3, Issue 6, pp 570–573

Heat shock protein 27 overexpression in breast cancer lymph node metastasis

  • F. Kristian Storm
  • David M. Mahvi
  • Kennedy W. Gilchrist
Original Articles

DOI: 10.1007/BF02306091

Cite this article as:
Storm, F.K., Mahvi, D.M. & Gilchrist, K.W. Annals of Surgical Oncology (1996) 3: 570. doi:10.1007/BF02306091

Abstract

Background: Heat shock protein 27 (hsp-27) is overexpressed in ∼67% pure ductal carcinoma in situ (DCIS), in ∼50% DCIS associated with invasive ductal carcinoma (IDC), and in ∼25% IDC alone. If this decrease in hsp-27 expression has a role in the progression of malignancy in IDC, we postulate a further reduction in expression in nodal metastasis.

Methods: To test this hypothesis, we evaluated the distribution of hsp-27 in primary IDC and in synchronous regional lymph node metastasis within the same patient by immunohistochemistry.

Results: Nine of 30 primary IDCs (30%) and 22 of 30 lymph node metastases (73%) overexpressed hsp-27. Contrary to our hypothesis, of 21 IDCs with no or low hsp-27 expression, 13 (62%) had overexpression of this protein within nodal metastasis.

Conclusions: hsp-27 appears to confer cytoprotection for metastatic cells, which may help explain why hsp-27 overexpression is associated with reduced disease-free survival in breast carcinomas.

Key Words

Heat shock protein 27Breast cancerMetastasis

Copyright information

© The Society of Surgical Oncology, Inc. 1996

Authors and Affiliations

  • F. Kristian Storm
    • 1
  • David M. Mahvi
    • 1
  • Kennedy W. Gilchrist
    • 2
  1. 1.From the Department of Surgery, Section of OncologyUniversity of Wisconsin School of Medicine and the Comprehensive Cancer CenterMadisonUSA
  2. 2.Department of Pathology and Laboratory MedicineUniversity of Wisconsin School of Medicine and the Comprehensive Cancer CenterMadisonUSA
  3. 3.University of Wisconsin, Clinical Science Center H4/724MadisonUSA