Heat shock protein 27 overexpression in breast cancer lymph node metastasis
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Background: Heat shock protein 27 (hsp-27) is overexpressed in ∼67% pure ductal carcinoma in situ (DCIS), in ∼50% DCIS associated with invasive ductal carcinoma (IDC), and in ∼25% IDC alone. If this decrease in hsp-27 expression has a role in the progression of malignancy in IDC, we postulate a further reduction in expression in nodal metastasis.
Methods: To test this hypothesis, we evaluated the distribution of hsp-27 in primary IDC and in synchronous regional lymph node metastasis within the same patient by immunohistochemistry.
Results: Nine of 30 primary IDCs (30%) and 22 of 30 lymph node metastases (73%) overexpressed hsp-27. Contrary to our hypothesis, of 21 IDCs with no or low hsp-27 expression, 13 (62%) had overexpression of this protein within nodal metastasis.
Conclusions: hsp-27 appears to confer cytoprotection for metastatic cells, which may help explain why hsp-27 overexpression is associated with reduced disease-free survival in breast carcinomas.
- Heat shock protein 27 overexpression in breast cancer lymph node metastasis
Annals of Surgical Oncology
Volume 3, Issue 6 , pp 570-573
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- Heat shock protein 27
- Breast cancer
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- 1. From the Department of Surgery, Section of Oncology, University of Wisconsin School of Medicine and the Comprehensive Cancer Center, Madison, Wisconsin, USA
- 3. Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and the Comprehensive Cancer Center, Madison, Wisconsin, USA