Annals of Surgical Oncology

, Volume 5, Issue 1, pp 77–80

Lack of effect of particle size on the identification of the sentinel node in cutaneous malignancies


  • Jan H. Wong
    • Dept. of SurgeryUniversity of Hawaii School of Medicine
  • Keith Terada
    • the Department of Obstetrics and GynecologyUniversity of Hawaii School of Medicine
  • Peter Ko
    • the Department of Nuclear MedicineQueen's Medical Center
  • Marc N. Coel
    • the Department of Nuclear MedicineQueen's Medical Center
Original Articles

DOI: 10.1007/BF02303767

Cite this article as:
Wong, J.H., Terada, K., Ko, P. et al. Annals of Surgical Oncology (1998) 5: 77. doi:10.1007/BF02303767


Background: Radiotracers have become a routine technical component of the new procedure of intraoperative lymphatic mapping and selective lymphadenectomy. Because different colloids have differing physicochemical properties, their distribution and uptake may be different. For this reason, the optimal colloid to identify and localize the sentinel node remains controversial.

Methods: Nineteen consecutive patients with cutaneous malignancies underwent diagnostic lymphoscintigraphy with99mTc-labeled human serum albumin (99mTc-HSA) and preoperative lymphoscintigraphy with99mTc-labeled sulfur colloid (99mTc-SC). The results of intraoperative lymphatic mapping and selective lymphadenectomy were reviewed.

Results: Intraoperative lymphatic mapping and selective node dissection were successful in 21 of 22 lymphatic basins (18 of 19 patients). There was excellent correlation between the “hot” marker placed on the skin surface when99mTc-HSA was used compared with the use of99mTc-SC. In 20 of 21 lymphatic basins the sentinel node both was “hot” and was stained with isosulfan blue.

Conclusions: No discernible difference between the ability to localize in the sentinel node with these two radiocolloids was identified. For logistical reasons,99mTC-SC appears to be the colloid of choice in intraoperative lymphatic mapping.

Key Words

MelanomaSentinel lymph nodeTechnetium-labeled human serum albuminTechnetium-labeled sulfur colloid
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Copyright information

© The Society of Surgical Oncology, Inc. 1998