Annals of Surgical Oncology

, Volume 1, Issue 4, pp 314–320

Effect of growth hormone on tumor and host in an animal model

  • Ronald F. Wolf
  • Bruce Ng
  • Benny Weksler
  • Michael Burt
  • Murray F. Brennan
Article

DOI: 10.1007/BF02303570

Cite this article as:
Wolf, R.F., Ng, B., Weksler, B. et al. Annals of Surgical Oncology (1994) 1: 314. doi:10.1007/BF02303570

Abstract

Background: The relative effects of growth hormone on tumor versus host growth and protein metabolism are not known. This study examines the influence of recombinant rat growth hormone (r-rGH) on host and tumor growth, host body composition, and protein synthesis of tumor and host in tumor-bearing rats.

Methods: After left flank implantation of methylcholanthrene-induced sarcoma, 28 Fischer rats with palpable tumor were treated with s.c. saline or 1 mg/kg/day r-rGH for 11 days. At death, fractional protein synthetic rates (FSRs) of tumor, liver, and gastrocnemius muscle were determined. In a separate experiment, 27 tumor-bearing rats received saline or 1 mg/kg/day r-rGH for 2 weeks. Tumor and host growth and host body composition were analyzed.

Results: Animals treated with r-rGH had significantly higher liver FSR than did controls (233 ± 27%/day vs. 110 ± 4%/day, respectively). No significant differences were associated with growth hormone administration with respect to tumor growth, host composition, or FSR of tumor or muscle.

Conclusions: Growth hormone stimulates liver protein synthesis, without changing tumor growth, protein synthesis, or host composition in this rat sarcoma model. Further investigation of growth hormone as an anticachectic agent is warranted.

Key Words

Somatotropin Tumor Cachexia Metabolism Protein 

Copyright information

© The Society of Surgical Oncology, Inc 1994

Authors and Affiliations

  • Ronald F. Wolf
    • 1
  • Bruce Ng
    • 1
  • Benny Weksler
    • 1
  • Michael Burt
    • 1
  • Murray F. Brennan
    • 1
  1. 1.From the Surgical Metabolism Laboratory, Department of SurgeryMemorial Sloan-Kettering Cancer CenterNew YorkUSA