Original Articles

Annals of Surgical Oncology

, Volume 5, Issue 8, pp 695-698

Long-term survival in patients with ovarian metastases from colorectal carcinoma

  • Peter P. HuangAffiliated withFrom the Division of Surgical Oncology, Roswell Park Cancer Institute, State University of New York at Buffalo
  • , Thomas K. WeberAffiliated withFrom the Division of Surgical Oncology, Roswell Park Cancer Institute, State University of New York at Buffalo
  • , Carlos MendozaAffiliated withFrom the Division of Surgical Oncology, Roswell Park Cancer Institute, State University of New York at Buffalo
  • , Miguel A. Rodriguez-BigasAffiliated withFrom the Division of Surgical Oncology, Roswell Park Cancer Institute, State University of New York at Buffalo
  • , Nicholas J. PetrelliAffiliated withFrom the Division of Surgical Oncology, Roswell Park Cancer Institute, State University of New York at Buffalo

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Abstract

Background: Ovarian metastases (OM) are a relatively uncommon consequence of primary colorectal carcinoma (CRC). The authors present a retrospective review of the impact of elective and therapeutic oophorectomy on the natural history of CRC.

Methods: Patients with primary CRC from January 1964 through March 1996 were reviewed. Survival from the time of OM diagnosis was estimated by the Kaplan-Meier method; differences between groups were based on the log-rank test.

Results: A total of 155 patients were studied. Synchronous OM occurred in 90 patients (58.1%); metachronous OM occurred in 65 patients (41.9%). Estimated 5-year survival for patients with synchronous OM was 9%, versus 20% for metachronous OM (P<.0001). Resection of metastatic disease was associated with an improved 5-year survival for synchronous OM (15% vs. 0%,P=.0001) and metachronous OM (24% vs. 0%,P<.0001) if patients were disease-free postoperatively. Other clinical characteristics, including age, menopausal status, stage, and location of primary tumor, had no significant impact on survival.

Conclusions: Ovarian metastases from colorectal carcinoma are associated with a poor outcome. Although there is no survival advantage associated with resection of occult microscopic disease, long-term survival is possible if patients are rendered surgically disease-free.

Key Words

Colorectal carcinoma Surgery Ovarian Metastases Survival