Somatic Cell and Molecular Genetics

, Volume 20, Issue 2, pp 75–86

Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse

  • Athena Milatovich
  • Graeme Bolger
  • Tamar Michaeli
  • Uta Francke
Article

DOI: 10.1007/BF02290677

Cite this article as:
Milatovich, A., Bolger, G., Michaeli, T. et al. Somat Cell Mol Genet (1994) 20: 75. doi:10.1007/BF02290677

Abstract

Cyclic nucleotides are important second messengers that mediate a number of cellular responses to external signals. Cyclic nucleotide phosphodiesterases play a role in signal transduction by regulating the cellular concentrations of these messengers. Here, we have applied Southern analyses of somatic cell hybrid lines and of recombinant inbred (RI) mouse strains as well as fluorescence chromosomal in situ hybridization (FISH) to chromosomally localize five cAMP-specific nucleotide phosphodiesterase genes in human and mouse. GenesDPDE1, DPDE2, DPDE3, andDPDE4 that share sequence homology with theDrosophila dunce gene were assigned to human chromosomes 19 (DPDE1 andDPDE2), 5q12 (DPDE3), and 1p31 (DPDE4) and to mouse chromosomes 8, 9, 13, and 4, respectively. The high-affinity cAMP-specific phosphodiesterase gene (HCP1) was mapped to human chromosome 8q13-q22. Since these genes are potential candidates for involvement in psychiatric or behavioral disorders, knowledge of their chromosomal localizations will facilitate the discovery of their association with disease genes as they are being mapped by linkage studies.

Copyright information

© Plenum Publishing Corporation 1994

Authors and Affiliations

  • Athena Milatovich
    • 1
  • Graeme Bolger
    • 4
  • Tamar Michaeli
    • 4
  • Uta Francke
    • 1
    • 2
    • 3
  1. 1.Department of GeneticsStanford University Medical CenterStanford
  2. 2.PediatricsStanford University Medical CenterStanford
  3. 3.Howard Hughes Medical InstituteStanford University Medical CenterStanford
  4. 4.Cold Spring Harbor LaboratoryNew York
  5. 5.Division of GeneticsCincinnati Children's HospitalCincinnati
  6. 6.Hematology-Oncology Division, School of MedicineUniversity of UtahSalt Lake City
  7. 7.Department of Developmental Biology and CancerAlbert Einstein College of MedicineBronx