Review

European Journal of Pediatrics

, Volume 155, Issue 11, pp 921-927

First online:

Inherited defects of the protein C anticoagulant system in childhood thrombo-embolism

  • U. Nowak-GöttlAffiliated withDepartment of Paediatrics, Paediatric Haematology and Oncology, Westfälische Wilhelms-Universität
  • , K. AubergerAffiliated withDepartment of Paediatrics, University Hospital
  • , U. GöbelAffiliated withDepartment of Paediatrics, University Hospital
  • , W. KreuzAffiliated withDepartment of Paediatrics, University Hospital
  • , R. SchneppenheimAffiliated withDepartment of Paediatrics, University Hospital
  • , H. VielhaberAffiliated withDepartment of Paediatrics, Paediatric Haematology and Oncology, Westfälische Wilhelms-Universität
  • , W. ZenzAffiliated withDepartment of Paediatrics, University Hospital
  • , B. ZiegerAffiliated withDepartment of Paediatrics, University Hospital

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Abstract

Childhood thrombo-embolism is mostly the result of inherited thrombophilia or vascular insults combined with risk factors such as peripartal asphyxia, fetopathia diabetica, exsiccosis, septicaemia, central lines, congenital heart disease, cancer, trauma, surgery or elevated antiphospholipid antibodies. Inherited thrombophilia includes mainly defects of the protein C pathway, resistance to activated protein C, protein C or protein S deficiency. Resistance to activated protein C, in the majority of cases caused by the point mutation Arg 506 Gln of the factor V gene, has emerged as the most important hereditary cause of thrombo-embolism in adults and children. However, since an acquired risk of thrombo-embolic complications frequently masks the inherited deficiency in affected children, children with thrombo-embolism should have adequate laboratory evaluation for inherited coagulation disorders, especially the protein C pathway. Until more data on childhood thrombo-embolism are available, treatment recommendations will continue to be extrapolated from guidelines for adults.

Key words

Resistance to activated protein C (APCR) Protein C Protein S Childhood thrombo-embolism