Hematology/Oncology

European Journal of Pediatrics

, Volume 155, Issue 10, pp 880-884

First online:

Molecular analysis of medulloblastomas occurring simultaneously in monozygotic twins

  • W. ScheurlenAffiliated withDepartment of Paediatrics, University of Würzburg
  • , N. SörensenAffiliated withDepartment of Paediatric Neurosurgery, University of Würzburg
  • , W. RoggendorfAffiliated withDepartment of Neuropathology, University of Würzburg
  • , J. KühlAffiliated withDepartment of Paediatrics, University of Würzburg

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Abstract

We report male monocygotic twins with concordant desmoplastic medulloblastoma diagnosed at the age of 20 months. Both tumours were completely removed. As chromosomal loci 17p13 and 9831 are frequently altered in medulloblastoma these regions were analysed in both tumours in detail using restriction fragment length polymorphism and microsatellite analysis. No common aberration was found. The c-myc gene on chromosome 8g21 was not amplified.

Key words

Medulloblastoma Monozygotic twins Loss of heterozygosity Chromosome l7p 13 and 9g31