Clinical and physiological characteristics of autonomic failure with Parkinson's disease
Purchase on Springer.com
$39.95 / €34.95 / £29.95*
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.
We analyzed the clinical and physiological features of autonomic failure with Parkinson's disease (AF-PD) in seven patients and compared them with those of autonomic failure with multiple system atrophy (AF-MSA). In AF-PD, parkinsonism was more gradually progressive than in AF-MSA, and symptoms were responsive to L-dopa. All seven patients with AF-PD had orthostatic hypotension, postprandial hypotension, and constipation, but no urinary retention. Of these, three had hypohidrosis and five had frequent urination; five patients had subnormal plasma norepinephrine (NE) concentrations. Supersensitivity to NE infusion was observed in all patients. Head-up tilting (HUT) test resulted in no increase of plasma NE concentrations in both groups, but a significant increase of the plasma arginine vasopressin (AVP) concentrations in the patients with AF-PD. Urodynamic studies revealed that urinary bladder function was relatively well preserved in AF-PD in contrast to AF-MSA. In conclusion, there exists some clinical and physiological differences in autonomic features between AF-PD and AF-MSA, and postganglionic involvement predominates in AF-PD.
- Bannister R, Mathias CJ. Clinical features and investigation of the primary autonomic failure syndromes. In:Autonomic failure — a textbook of clinical disorders of the autonomic nervous system, 3rd ed. Bannister R, Mathias CJ, eds. Oxford: Oxford University Press; 1992:531–547.
- Koike Y, Takahashi A. Autonomic dysfunction in Parkinson's disease.Eur Neurol 1997; 38:8–12.
- Schatz IJ, Bannister R, Freeman L, Goetz CG, Jankovic J, Kaufmann HC, Koller WC, Low PA, Mathias CJ, Polinsky RJ, Quinn NP, Robertson D, Streeten DHP. Consensus statement on the definition of orthostatic hypotension, pure autonomic failure and multiple system atrophy.Neurology 1996; 46:1470.
- Hasegawa Y, Takahashi A. Progressive autonomic failure with Parkinson's disease (Japanese).Nippon-Rinsho 1992; 50:790–798.
- Mathias CJ, Bannister R. Investigation of autonomic disorders. In:Autonomic failure—A textbook of clinical disorders of the autonomic nervous system, Third ed. Bannister R, Mathias CJ, eds. Oxford: Oxford University Press; 1992:277–284.
- Ohkuea Y, Nohta H. Fluorogenic reagents for the derivatization of catecholamines and related compounds for liquid chromatographic analysis of biological samples.Trends Analyt Chem 1992; 2:74–79.
- Kimura T, Matsui K, Ota K, Yoshinaga K. Radioimmunoassay of arginine vasopressin in human plasma and urine, a resin microcolumn method.Tohoku J Exp Med 1980; 131:37–46.
- Gilman S, Low P, Quinn N, Albanese A, Ben-Shimo Y, Fowler C, Kaufmann H, Klockgether T, Lang A, Lantos P, Litvan I, Mathias C, Oliver E, Robertson D, Schatz I, Wenning G. Consensus statement on the diagnosis of multiple system atrophy.Clin Auton Res 1999; 8:359–362.
- Micieli G, Martignoni E, Cavallini A, Sandrini G, Nappi G. Postprandial and orthostatic hypotension in Parkinson's disease.Neurology 1987; 37:386–393.
- Hasegawa Y, Matsuoka Y, Ieda T, Koike Y, Hakusui S, Takahashi A. Effect of standing on blood pressure, plasma vasopressin and norepinephrine in Parkinson's disease.New Trends Clin Neuropharmacol 1994; 8:133.
- Ieda T, Hirayama M, Niimi Y, Kodama Y, Takeuch Y, Koike Y, et al. Pharmacological assessments of cardiovascular adrenoreceptor functions in five patients suffering from autonomic failure with Parkinson's disease.Clin Auton Res 1995; 5:333 (Abstract).
- Zerbe RL, Henry DP, Robertson GL. Vasopressin response to orthostatic hypotension.Am J Med 1983; 74:265–271.
- Andersen JT, Hebjørn S, Frimodt-Møller C, Walter S, Worm-Petersen J. Disturbances of micturition in Parkinson's disease.Acta Neurol Scand 1976; 53:161–170.
- Lewin RJ, Dillard GV, Porter RW. Extrapyramidal inhibition of the urinary bladder.Brain Res 1967; 4:301–307.
- Sung J, Mastri AR, Segal E. Pathology of the Shy-Drager syndrome.J Neuropathol Exp Neurol 1978; 38:253–268.
- Polinsky RJ. Neuropharmacological investigation of autonomic failure. In:Autonomic failure—A textbook of clinical disorders of the autonomic nervous system, Third Edition. Bannister R, Mathias CJ, eds. Oxford: Oxford University Press; 1992:335–358.
- Kaufmann H, Oribe E, Miller M, Knott P, Wiltshire-Clement M, Yahr MD. Hypotension-induced vasopressin release distinguishes between pure autonomic failure and multiple system atrophy with autonomic failure.Neurology 1992; 42:590–593.
- Fichefet JP, Sternon JE, Franken L, Demanet JC, Vanderhaeghen JJ. Etude anatomo-clinique d'un cas d'hypotension orthostatique ‘idiopathique’: Considerations pathogeniques.Acta Cardiol (Brux) 1965; 20:332–348.
- Oppenheimer D. Neuropathology and neurochemistry of autonomic failure. In:Autonomic failure—A textbook of clinical disorders of the autonomic nervous system, Second Edition. Bannister R, Mathias CJ, eds. Oxford: Oxford University Press; 1988: 451–463.
- Bannister R, Oppenheimer D. Degenerative diseases of the nervous system associated with autonomic failure.Brain 1972; 95:457–474.
- Clinical and physiological characteristics of autonomic failure with Parkinson's disease
Clinical Autonomic Research
Volume 9, Issue 3 , pp 139-144
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- autonomic failure
- Parkinson's disease
- multiple system atrophy
- pure autonomic failure
- Industry Sectors
- Author Affiliations
- 1. Department of Neurology, Nagoya University School of Medicine, Nagoya, Japan
- 3. Nagoya University College of Medical Technology, Nagoya, Japan
- 4. Department of Neurology, Higashi Municipal Hospital of Nagoya, Nagoya, Japan
- 5. Tokal Central Hospital, Kakamigahara, Japan