European Archives of Psychiatry and Clinical Neuroscience

, Volume 240, Issue 6, pp 331–333

Glucose metabolism in the caudate nuclei of patients with eating disorders, measured by PET

  • J. -C. Krieg
  • V. Holthoff
  • W. Schreiber
  • K. M. Pirke
  • K. Herholz
Original Articles

DOI: 10.1007/BF02279762

Cite this article as:
Krieg, J.C., Holthoff, V., Schreiber, W. et al. Eur Arch Psychiatry Clin Nuerosci (1991) 240: 331. doi:10.1007/BF02279762

Summary

Regional cerebral glucose metabolism was measured with18F-2-fluoro-2-deoxyglucose and positron emission tomography in nine patients with bulimia nervosa and in seven patients with anorexia nervosa. Relative caudate glucose metabolism (caudate glucose metabolism divided by global cerebral glucose metabolism) was significantly higher in anorexia nervosa than in bulimia nervosa, suggesting that caudate hyperactivity is characteristic of the anorexic state. Whether increased caudate function is a consequence of anorexic behaviour or whether it is directly involved in the pathogenesis of anorexia nervosa is an issue still to be clarified.

Key words

Bulimia nervosaAnorexia nervosaCaudate nucleiGlucose metabolismPositron emission tomography

Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • J. -C. Krieg
    • 1
  • V. Holthoff
    • 2
  • W. Schreiber
    • 1
  • K. M. Pirke
    • 1
  • K. Herholz
  1. 1.Clinical InstituteMax Planck Institute for PsychiatryMunichFederal Republic of Germany
  2. 2.Max Planck Institute for Neurological ResearchCologneFederal Republic of Germany