Short Communication

Journal of Neural Transmission - Parkinson's Disease and Dementia Section

, Volume 5, Issue 1, pp 63-65

Sequencing of exons 16 and 17 of the β-amyloid precursor protein gene reveals the β-amyloid sequence to be normal in cases of the parkinson dementia complex of guam

  • M. -C. Chartier HarlinAffiliated withAlzheimer's Disease Research Group, Departments of Biochemistry and Molecular Genetics, St. Mary's Hospital Medicial School
  • , F. CrawfordAffiliated withAlzheimer's Disease Research Group, Departments of Biochemistry and Molecular Genetics, St. Mary's Hospital Medicial School
  • , D. P. PerlAffiliated withNeuropathology Division, Mt. Sinai Medical Center
  • , J. SteeleAffiliated withGuam Memorial Hospital
  • , J. HardyAffiliated withAlzheimer's Disease Research Group, Departments of Biochemistry and Molecular Genetics, St. Mary's Hospital Medicial School

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Summary

Exons 16 and 17 of the β-amyloid precursor protein gene has been sequenced in individuals with the amyotropic lateral sclerosis/Parkinson's dementia complex of Guam to test the hypothesis that this disease is an allelic variant of Alzheimer's disease and to test whether sequence differences within β-amyloid in this population contributes to the non-deposition of this peptide in the disorder. The sequence was normal.

Keywords

β-amyloid APP amyotrophic lateral sclerosis Parkinson's disease Guam genetics Alzheimer's disease