Sequencing of exons 16 and 17 of the β-amyloid precursor protein gene reveals the β-amyloid sequence to be normal in cases of the parkinson dementia complex of guam
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- Chartier Harlin, M.C., Crawford, F., Perl, D.P. et al. J Neural Transm Gen Sect (1993) 5: 63. doi:10.1007/BF02260915
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Exons 16 and 17 of the β-amyloid precursor protein gene has been sequenced in individuals with the amyotropic lateral sclerosis/Parkinson's dementia complex of Guam to test the hypothesis that this disease is an allelic variant of Alzheimer's disease and to test whether sequence differences within β-amyloid in this population contributes to the non-deposition of this peptide in the disorder. The sequence was normal.