Full Papers

Journal of Neural Transmission - Parkinson's Disease and Dementia Section

, Volume 5, Issue 1, pp 27-34

First online:

The effects of L-threo-3,4-dihydroxyphenylserine on the total norepinephrine and dopamine concentrations in the cerebrospinal fluid and freezing gait in parkinsonian patients

  • H. TohgiAffiliated withDepartment of Neurology, Iwate Medical University
  • , T. AbeAffiliated withDepartment of Neurology, Iwate Medical University
  • , S. TakahashiAffiliated withDepartment of Neurology, Iwate Medical University

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We studied the effects of L-threo-DOPS (L-DOPS) on the concentrations of total (conjugated and unconjugated) dopamine (DA) and norepinephrine (NE) in the cerebrospinal fluid (CSF) of parkinsonian patients with freezing phenomenon. The NE concentration increased remarkably and dose-dependently after administration of L-DOPS in both L-dopa/carbidopa-pretreated and untreated patients. The DA concentration also increased mildly but significantly in L-dopa/carbidopa-untreated patients. Freezing phenomenon improved in 6 out of 8 patients at Hoehn and Yahr's stage III, and 1 out of 5 patients at stage IV. These results indicate that L-DOPS administration increases the NE concentration dosedependently, and is effective for freezing of gait of moderate severity.


L-threo-DOPS freezing of gait norepinephrine dopamine cerebrospinal fluid