Journal of Neural Transmission - Parkinson's Disease and Dementia Section

, Volume 5, Issue 1, pp 5–15

Concentration gradients for monoamine metabolites in lumbar cerebrospinal fluid

Authors

  • K. Blennow
    • Department of Psychiatry and NeurochemistryUniversity of Göteborg, Mölndal Hospital
  • A. Wallin
    • Department of Psychiatry and NeurochemistryUniversity of Göteborg, Mölndal Hospital
  • C. G. Gottfries
    • Department of Psychiatry and NeurochemistryUniversity of Göteborg, Mölndal Hospital
  • J. -E. Månsson
    • Department of Psychiatry and NeurochemistryUniversity of Göteborg, Mölndal Hospital
  • L. Svennerholm
    • Department of Psychiatry and NeurochemistryUniversity of Göteborg, Mölndal Hospital
Full Papers

DOI: 10.1007/BF02260910

Cite this article as:
Blennow, K., Wallin, A., Gottfries, C.G. et al. J Neural Transm Gen Sect (1993) 5: 5. doi:10.1007/BF02260910

Summary

Concentration gradients in lumbar cerebrospinal fluid (CSF) for the monoamine metabolites homovanillic acid (HVA), 5-hydroxy-indoleacetic acid (5-HIAA) and 4-hydroxy-3-methoxyphenylglycol (HMPG) were studied in 9 healthy controls and 47 neuropsychiatric patients without diseases causing disturbed CSF circulation. In a serial sampling of the first 24 ml of CSF, steep concentration gradients between the first (0–4 th ml) and last (21th–24th ml) portions of CSF were found for HVA (99±59% increase; p<0.001) and 5-HIAA (88±54% increase; p<0.001), while the concentration gradient was slight for HMPG (11±7% increase; p<0.001). The existence of marked concentration gradients for the monoamine metabolites HVA and 5-HIAA gives further evidence for an active transport system for these metabolites and indicates that the lumbar CSF-HVA and 5-HIAA levels reflect the dopamine and serotonin metabolism in the brain. Moreover, the existence of pronounced concentration gradients for HVA and 5-HIAA levels reflect the dopamine and serotonin metabolism in the brain. Moreover, the existence of pronounced concentration gradients for HVA and 5-HIAA stresses the importance of making analyses on a standardized volume of CSF.

Keywords

Homovanillic acid (HVA) 5-hydroxy-indoleacetic acid (5-HIAA) 4-hydroxy-3-methoxyphenylglycol (HMGP) cerebrospinal fluid (CSF) concentration gradients

Copyright information

© Springer-Verlag 1993