Journal of Neural Transmission - Parkinson's Disease and Dementia Section

, Volume 5, Issue 3, pp 235–244

Sleep, excessive daytime sleepiness and fatigue in Parkinson's disease

  • J. J. van Hilten
  • M. Weggeman
  • E. A. van der Velde
  • G. A. Kerkhof
  • J. G. van Dijk
  • R. A. C. Roos
Full Papers

DOI: 10.1007/BF02257678

Cite this article as:
van Hilten, J.J., Weggeman, M., van der Velde, E.A. et al. J Neural Transm Gen Sect (1993) 5: 235. doi:10.1007/BF02257678

Summary

The objective of this questionnaire-based survey was to evaluate the prevalence and causes of sleep disturbances in 90 nondepressive patients with Parkinson's disease (PD) and 71 age-matched healthy subjects. We also assessed the prevalence and characteristics of excessive daytime sleepiness (both groups) and excessive fatigue (PD patients).

A high prevalence of sleep disturbances in PD patients was found; this is to a large extent probably the result of aging. As compared with controls, patients had a more severely disturbed sleep maintenance because of nycturia, pain, stiffness, and problems with turning in bed. The prevalence of excessive dreaming is similar in both groups, but altered dream experiences almost exclusively occurred in PD.

Patients rated themselves more often to be morning-types than controls. This finding may account for the reported adaptation effects in experimental settings and the reduced REM latency in PD patients.

The prevalence of daytime sleepiness was similar in both groups. Excessive daytime sleepiness showed a clear diurnal pattern with a peak in the early afternoon. As for excessive fatigue, the majority of the patients did not report a preferential time for this symptom. Our findings further argue against an association of fatigue with any circadian factor, and instead suggest a relationship with the motor deficits of PD.

Keywords

Sleepdaytime sleepinessfatigueParkinson's disease

Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • J. J. van Hilten
    • 4
    • 1
  • M. Weggeman
    • 4
    • 1
  • E. A. van der Velde
    • 2
  • G. A. Kerkhof
    • 3
  • J. G. van Dijk
    • 4
    • 1
  • R. A. C. Roos
    • 4
    • 1
  1. 1.Clinical NeurophysiologyAcademic HospitalLeidenThe Netherlands
  2. 2.Department of Medical StatisticsState UniversityLeidenThe Netherlands
  3. 3.Department of PhysiologyState UniversityLeidenThe Netherlands
  4. 4.Department of NeurologyAcademic HospitalLeidenThe Netherlands