Decreased uptake and binding of11C-nicotine in brain of Alzheimer patients as visualized by positron emission tomography
- Cite this article as:
- Nordberg, A., Hartvig, P., Lilja, A. et al. J Neural Transm Gen Sect (1990) 2: 215. doi:10.1007/BF02257652
- 86 Downloads
Positron emission tomography of the brain following intravenous injection of (+) (R) and (−) (S) N-[11C-methyl]nicotine showed a marked reduced uptake of both isomers, especially the (R) form, in Alzheimer patients as compared to age-matched controls. The significantly larger difference between the uptake values of the (S)- and (R)-enantiomers of11C-nicotine in Azheimer brains may be of diagnostic value.