Decreased uptake and binding of11C-nicotine in brain of Alzheimer patients as visualized by positron emission tomography

  • A. Nordberg
  • P. Hartvig
  • A. Lilja
  • M. Viitanen
  • K. Amberla
  • H. Lundqvist
  • Y. Andersson
  • J. Ulin
  • B. Winblad
  • B. Långström
Short Communication

DOI: 10.1007/BF02257652

Cite this article as:
Nordberg, A., Hartvig, P., Lilja, A. et al. J Neural Transm Gen Sect (1990) 2: 215. doi:10.1007/BF02257652

Summary

Positron emission tomography of the brain following intravenous injection of (+) (R) and (−) (S) N-[11C-methyl]nicotine showed a marked reduced uptake of both isomers, especially the (R) form, in Alzheimer patients as compared to age-matched controls. The significantly larger difference between the uptake values of the (S)- and (R)-enantiomers of11C-nicotine in Azheimer brains may be of diagnostic value.

Keywords

Positron emission tomography PET Alzheimer's disease (+) (R) N-11C-methyl nicotine (−) (S) N-11C-methyl nicotine brain nicotinic receptors cholinergic receptors diagnostic marker 

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • A. Nordberg
    • 1
    • 6
  • P. Hartvig
    • 5
  • A. Lilja
    • 3
  • M. Viitanen
    • 6
  • K. Amberla
    • 6
  • H. Lundqvist
    • 4
  • Y. Andersson
    • 2
  • J. Ulin
    • 2
  • B. Winblad
    • 6
  • B. Långström
    • 2
  1. 1.Department of PharmacologyUniversity of UppsalaUppsalaSweden
  2. 2.Department of Organic ChemistryUniversity of UppsalaUppsalaSweden
  3. 3.Department of Diagnostic RadiologyUniversity of UppsalaUppsalaSweden
  4. 4.Department of The Svedberg LaboratoryUniversity of UppsalaUppsalaSweden
  5. 5.Hospital PharmacyUniversity HospitalUppsalaSweden
  6. 6.Department of Geriatric MedicineHuddinge Hospital, Karolinska InstituteStockholmSweden

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