Journal of Biomedical Science

, Volume 5, Issue 3, pp 153–172

Thromboxanes: Synthase and receptors

  • Rong-Fong Shen
  • Hsin-Hsiung Tai
Review

DOI: 10.1007/BF02253465

Cite this article as:
Shen, RF. & Tai, HH. J Biomed Sci (1998) 5: 153. doi:10.1007/BF02253465

Abstract

Thromboxane A2 is a biologically potent arachidonate metabolite through the cyclooxygenase pathway. It induces platelet aggregation and smooth muscle contraction and may promote mitogenesis and apoptosis of other cells. Its roles in physiological and pathological conditions have been widely documented. The enzyme that catalyzes its synthesis, thromboxane A2 synthase, and the receptors that mediate its actions, thromboxane A2 receptors, are the two key components critical for the functioning of this potent autacoid. Recent molecular biological studies have revealed the structure-function relationship and gene organizations of these proteins as well as genetic and epigenetic factors modulating their gene expression. Future investigation should shed light on detailed molecular signaling events specifying thromboxane A2 actions, and the genetic underpinning of the enzyme and the receptors in health and disease.

Key Words

Thromboxane synthase Thromboxane A2 receptor Gene structure and regulation Structure and activity Molecular pharmacology Signal transduction 

Copyright information

© National Science Council 1998

Authors and Affiliations

  • Rong-Fong Shen
    • 1
  • Hsin-Hsiung Tai
    • 2
  1. 1.Division of Human Genetics, Department of Obstetrics, Gynecology, and Reproductive Sciences and Center for the Genetics of Asthma and Other Complex DiseasesUniversity of Maryland School of MedicineBaltimore
  2. 2.Division of Medicinal Chemistry and Pharmaceutics, College of PharmacyUniversity of KentuckyLexingtonUSA

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