Brain β2-microglobulin levels are elevated in the striatum in Parkinson's diseaselevels are elevated in the striatum in Parkinson's disease

  • M. Mogi
  • M. Harada
  • T. Kondo
  • P. Riederer
  • T. Nagatsu
Short Communication

DOI: 10.1007/BF02252965

Cite this article as:
Mogi, M., Harada, M., Kondo, T. et al. J Neural Transm Gen Sect (1995) 9: 87. doi:10.1007/BF02252965

Summary

β2-Microglobulin (B2-MG) content was measured for the first time in the brain (caudate nucleus, putamen, and cerebral cortex) from control and parkinsonian patients by a highly sensitive sandwich enzyme immunoassay. The concentrations of B2-MG in dopaminergic striatal regions were significantly higher in parkinsonian patients than those in controls, whereas those in the cerebral cortex showed no significant difference between parkinsonian and control subjects. Tumor necrosis factor-α (TNF-α) concentrations were also increased in the striatum, confirming our previous findings, but not in the cerebral cortex. Since TNF-α may induce B2-MG expression, these results suggest that an immunological response may occur in the nigrostriatal dopaminergic regions in Parkinson's disease.

Keywords

β2-Microglobulintumor necrosis factor-αParkinson's diseasebrain

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • M. Mogi
    • 1
  • M. Harada
    • 1
  • T. Kondo
    • 2
  • P. Riederer
    • 3
  • T. Nagatsu
    • 4
  1. 1.Department of Oral BiochemistryMatsumoto Dental CollegeShiojiriJapan
  2. 2.Department of NeurologyJuntendo University School of MedicineTokyoJapan
  3. 3.Department of PsychiatryUniversity of WürzburgWürzburgFederal Republic of Germany
  4. 4.Institute for Comprehensive Medical Science, School of MedicineFujita Health UniversityToyoake, AichiJapan