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Journal of Neural Transmission - Parkinson's Disease and Dementia Section

, Volume 2, Issue 4, pp 327-340

Brain iron and ferritin in Parkinson's and Alzheimer's diseases

  • K. JellingerAffiliated withLudwig Boltzmann Institute of Clinical Neurobiology, Lainz Hospital
  • , W. PaulusAffiliated withLudwig Boltzmann Institute of Clinical Neurobiology, Lainz Hospital
  • , I. Grundke-IqbalAffiliated withNYS Institute for Basic Research in Developmental Disabilities
  • , P. RiedererAffiliated withClinical Neurochemistry, Department of Psychiatry, University of Würzburg School of Medicine
  • , M. B. H. YoudimAffiliated withDepartment of Pharmacology, Technion, Faculty of Medicine

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Summary

Semiquantitative histological evaluation of brain iron and ferritin in Parkinson's (PD) and Alzheimer's disease (DAT) have been performed in paraffin sections of brain regions which included frontal cortex, hippocampus, basal ganglia and brain stem. The results indicate a significant selective increase of Fe3+ and ferritin in substantia nigra zona compacta but not in zona reticulata of Parkinsonian brains, confirming the biochemical estimation of iron. No such changes were observed in the same regions of DAT brains. The increase of iron is evident in astrocytes, macrophages, reactive microglia and non-pigmented neurons, and in damaged areas devoid of pigmented neurons. In substantia nigra of PD and PD/DAT, strong ferritin reactivity was also associated with proliferated microglia. A faint iron staining was seen occasionally in peripheral halo of Lewy bodies. By contrast, in DAT and PD/DAT, strong ferritin immunoreactivity was observed in and around senile plaques and neurofibrillary tangles. The interrelationship between selective increase of iron and ferritin in PD requires further investigation, because both changes could participate in the induction of oxidative stress and neuronal dath, due to their ability to promote formation of oxygen radicals.

Keywords

Iron ferritin Parkinson's disease Alzheimer's disease melanin Lewy body