Polymorphisms of dopamine receptor and transporter genes and Parkinson's disease

  • S. Higuchi
  • T. Muramatsu
  • H. Arai
  • M. Hayashida
  • H. Sasaki
  • J. Q. Trojanowski
Full Papers

DOI: 10.1007/BF02251226

Cite this article as:
Higuchi, S., Muramatsu, T., Arai, H. et al. J Neural Transm Gen Sect (1995) 10: 107. doi:10.1007/BF02251226

Summary

Disturbances of the dopamine system are involved in the pathogenesis of idiopathic Parkinson's disease (PD). Although genetic factors may play a role in the etiology of PD, there is little direct evidence implicating a specific gene. We conducted a study to test the hypothesis that allelic variations of the dopamine receptors (D2, D3, D4) and the dopamine transporter (DAT) contribute to the susceptibility to PD. Association analyses of 70 Japanese PD patients and the same number of age-matched controls did not reveal any association between alleles of the D2, D3 or D4 receptor genes or the DAT gene and PD. Thus, our results suggest that factor(s) other than allelic variations of these key proteins in the dopamine system contribute to the susceptibility to PD.

Keywords

Parkinson's diseasedopamine D2 receptordopamine D3 receptordopamine D4 receptordopamine transporter

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • S. Higuchi
    • 3
  • T. Muramatsu
    • 3
  • H. Arai
    • 1
  • M. Hayashida
    • 3
  • H. Sasaki
    • 1
  • J. Q. Trojanowski
    • 2
  1. 1.Department of Geriatric Medicine, Tohoku UniversitySchool of MedicineSendai, MiyagiJapan
  2. 2.Division of Anatomic PathologyDepartment of Pathology and Laboratory Medicine, University of PennsylvaniaPhiladelphiaUSA
  3. 3.National Institute on Alcoholism, Kurihama National HospitalKanagawaJapan