Effect of a selective MAO-A inhibitor (Ro 41-1049) on striatal L-dopa and dopamine metabolism: An in vivo study

  • T. Brannan
  • A. Prikhojan
  • M. D. Yahr
Full Papers

DOI: 10.1007/BF02250920

Cite this article as:
Brannan, T., Prikhojan, A. & Yahr, M.D. J Neural Transm Gen Sect (1994) 8: 99. doi:10.1007/BF02250920

Summary

We administered Ro 41-1049, an inhibitor of the enzyme monoamine oxidase type A (MAO-A) to rats and monitored extracellular catecholamine levels in the corpus striatum before and after the intraperitoneal (IP) administration of a bolus of L-dopa. Acute administration of Ro 41-1049 (1–50 mg/kg IP) produced a dose-dependent decrease in basal levels of the dopamine metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) and an increase in basal levels of dopamine. In rats treated with Ro 41-1049 (20 mg/kg IP), L-dopa administration (100 mg/kg IP) produced a greater increase in striatal levels of dopamine than it did in controls, while DOPAC and HVA formation was attenuated. We conclude that inhibition of central MAO-A activity promotes synaptic accumulation of dopamine following administration of pharmacological doses of L-dopa.

Key words

Monoamine oxidase type A MAO-A dopamine depression Parkinson's disease cerebral microdialysis 

Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • T. Brannan
    • 1
  • A. Prikhojan
    • 1
  • M. D. Yahr
    • 1
  1. 1.Department of NeurologyMount Sinai School of MedicineNew YorkU.S.A.

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