Psychopharmacology

, Volume 114, Issue 3, pp 477–485

Bilateral intra-accumbens self-administration ofd-amphetamine: Antagonism with intra-accumbens SCH-23390 and sulpiride

  • Gavin D. Phillips
  • Trevor W. Robbins
  • Barry J. Everitt
Original Investigations

DOI: 10.1007/BF02249339

Cite this article as:
Phillips, G.D., Robbins, T.W. & Everitt, B.J. Psychopharmacology (1994) 114: 477. doi:10.1007/BF02249339

Abstract

The efficacy ofd-amphetamine to support a selective bilateral intra-accumbens self-administration response was examined. Bilateral intra-accumbens infusions ofd-amphetamine were made contingent upon the acquisition of a lever-pressing response. Two identical levers were available within the operant chamber. Depression of the drug lever resulted in the intra-accumbens delivery of 1 µgd-amphetamine; responses upon the second, control lever were recorded but had no programmed consequences. Animals were not ‘primed’ with non-contingent infusions ofd-amphetamine at any time during these experiments. Nonetheless, animals readily acquired a selective response upon the drug lever. Removal of thed-amphetamine moiety from the infusate resulted in a large decline in responding, and the abolition of the selectivity of the response for the drug lever. Adulteration of the infusate with either the D1 dopamine receptor antagonist SCH-23390 or the D2 dopamine receptor antagonist sulpiride enhanced the rate of response selectively upon the drug lever. Reductions in the dose ofd-amphetamine also increased the rate of response. The effect of co-adulteration of the infusate with both SCH-23390 and sulpiride together was purely additive. The implications of these data for the methodology of intracranial drug self-administration, and the relationship between D1 and D2 dopamine receptors within the nucleus accumbens are discussed.

Key words

Intracranial self-administrationd-AmphetamineDopamineNucleus accumbensSCH-23390Sulpiride

Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • Gavin D. Phillips
    • 1
  • Trevor W. Robbins
    • 2
  • Barry J. Everitt
    • 3
  1. 1.Department of PsychologyUniversity of YorkHeslingtonUK
  2. 2.Department of Experimental PsychologyUniversity of CambridgeCambridgeUK
  3. 3.Department of AnatomyUniversity of CambridgeCambridgeUK