Journal of Neural Transmission - Parkinson's Disease and Dementia Section

, Volume 1, Issue 3, pp 195–205

Uptake and regional distribution of (+)-(R)- and (−)-(S)-N-[methyl-11C]-nicotine in the brains of Rhesus monkey an attempt to study nicotinic receptors in vivo

Authors

  • A. Nordberg
    • Department of PharmacologyUniversity of Uppsala
  • P. Hartvig
    • Hospital PharmacyUniversity Hospital
  • H. Lundqvist
    • The Svedberg LaboratoryUniversity of Uppsala
  • G. Antoni
    • Department of Organic ChemistryUniversity of Uppsala
  • J. Ulin
    • Department of Organic ChemistryUniversity of Uppsala
  • B. Långström
    • Department of Organic ChemistryUniversity of Uppsala
Article

DOI: 10.1007/BF02248669

Cite this article as:
Nordberg, A., Hartvig, P., Lundqvist, H. et al. J Neural Transm Gen Sect (1989) 1: 195. doi:10.1007/BF02248669

Summary

N-[methyl-11C] nicotine (11C-nicotine) was given intravenously to monkeys and the uptake and regional distribution of radioactivity was followed in the brain using positron emission tomography (PET). The11C-radioactivity in the brain peaked within 1–2 min and then rapidly declined. Pretreatment with unlabelled nicotine (10 μg/kg) reduced the uptake of11C-radioactivity to the brain by 30%. The uptake of radioactivity was higher following (+)11C-nicotine than (−)11C-nicotine. Both enantiomers were distributed in a similar manner within the brain. When animals were infused with a peripheral nicotinic blocker (trimetaphan) the uptake of radioactivity to the brain was lower following (+)11C-nicotine compared to (−)11C-nicotine. The amount of radioactivity was high in the occipital cortex, thalamus, intermediate in the frontal cortex and low in white matter in (−)11C injected monkeys while no regional difference in distribution of11C-radioactivity was observed after injection of (+)11C-nicotine.

Keywords

Monkeypositron emission tomography11C-nicotineoptic enantiomersnicotinic receptorsbrainregional distribution

Copyright information

© Springer-Verlag 1989