Psychopharmacology

, Volume 121, Issue 4, pp 476–479

Effects of transderman nicotine on mood and sleep in nonsmoking major depresssed patients

  • R. J. Salín-Pascual
  • L. Galicia-Polo
  • R. Drucker-Colín
  • J. R. de la Fuente
  • R. Drucker-Colín
  • R. J. Salín-Pascual
Original Investigation

DOI: 10.1007/BF02246496

Cite this article as:
Salín-Pascual, R.J., Galicia-Polo, L., Drucker-Colín, R. et al. Psychopharmacology (1995) 121: 476. doi:10.1007/BF02246496

Abstract

The role of nicotine as an indirect cholinergic agent in sleep has been studied in normal subjects. There are no studies of its effects on sleep in depressed patients. Nicotine transdermal patches (17.5 mg), were studied in eight depressed patients (DSM-III-R) and eight normal volunteers. Subjects wore placebo and nicotine patches for 24 h. Depressed patients showed increased REM sleep without changes in other sleep variables. They also showed a short term improvement of mood. Normal volunteers had sleep fragmentation, and reduction of REM sleep time. No major side effects were reported in either group.

Key words

NicotineMajor depressionREM sleepCholinergic system

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • R. J. Salín-Pascual
    • 1
  • L. Galicia-Polo
    • 1
  • R. Drucker-Colín
    • 1
  • J. R. de la Fuente
    • 2
  • R. Drucker-Colín
    • 3
  • R. J. Salín-Pascual
    • 4
  1. 1.Depto de FisiologíaFacultad de Medicina, UNAMMexico DFMéxico
  2. 2.Depto de Psicologia Médica, Psiquiatría y Salud MentalFacultad de Medicina. UNAMMéxico DFMéxico
  3. 3.Depto de NeurocienciasInstituto de Fisiología Celular Facultad de Medicina, UNAMMéxico DFMéxico
  4. 4.Hospital Psiquíatrico “Fray Bernardino Alvarez”México