Psychopharmacology

, Volume 117, Issue 4, pp 417–423

A placebo-controlled trial of fluoxetine added to neuroleptic in patients with schizophrenia

  • D. C. Goff
  • E. Amico
  • O. Sarid-Segal
  • K. K. Midha
  • J. W. Hubbard
Original Investigation

DOI: 10.1007/BF02246213

Cite this article as:
Goff, D.C., Amico, E., Sarid-Segal, O. et al. Psychopharmacology (1995) 117: 417. doi:10.1007/BF02246213

Abstract

Following a 2-week placebo lead-in, schizophrenic patients were randomly assigned to fluoxetine 20 mg/day or placebo added to depot neuroleptic for a 6-week, double blind trial. All patients had received a stable dose of depot neuroleptic for at least 6 months and did not meet criteria for depression. Serum samples were obtained at baseline and at weeks 4 and 6. Scores on the negative symptom subscale of the Brief Psychiatric Rating Scale (BPRS) were significantly lower at week 6, controlling for baseline scores, in patients receiving fluoxetine (n=20) compared to patients receiving placebo (n=21). Measures of psychosis, depression, global functioning and extrapyramidal symptoms (EPS) did not differ between groups at week 6. Fluoxetine administration was associated with a mean 65% increase in serum fluphenazine concentrations in 15 patients and a mean 20% increase in serum haloperidol concentrations in three patients. The change in negative symptoms at week 6 did not correlate with serum concentrations of fluoxetine or norfluoxetine, but did inversely correlate withS-norfluoxetine, an active stereoisomer of fluoxetine. For these chronically ill patients, fluoxetine significantly improved negative symptoms and did not worsen EPS, despite causing substantial elevation in serum concentrations of neuroleptics.

Key words

FluoxetineSchizophreniaNeuroleptics

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • D. C. Goff
    • 1
    • 2
  • E. Amico
    • 1
  • O. Sarid-Segal
    • 3
  • K. K. Midha
    • 4
  • J. W. Hubbard
    • 4
  1. 1.Freedom Trail ClinicBostonUSA
  2. 2.Psychiatry ServiceMassachusetts General HospitalBostonUSA
  3. 3.Boston Veterans Affairs Outpatient ClinicBostonUSA
  4. 4.College of Pharmacy and MedicineUniversity of SaskatchewanSaskatoonCanada