Psychopharmacology

, Volume 122, Issue 2, pp 115–121

Bretazenil modulates sleep EEG and nocturnal hormone secretion in normal men

  • J. Guldner
  • L. Trachsel
  • C. Kratschmayr
  • B. Rothe
  • F. Holsboer
  • A. Steiger
Original Investigation

DOI: 10.1007/BF02246085

Cite this article as:
Guldner, J., Trachsel, L., Kratschmayr, C. et al. Psychopharmacology (1995) 122: 115. doi:10.1007/BF02246085

Abstract

Preclinical data suggest that the imidazo-diazepinone derivative bretazenil (Ro 16-6028) has anxiolytic and anticonvulsant properties with only weak sedative effects. We examined the influence of oral administration of 1 mg bretazenil on the sleep EEG and the concomitant nocturnal secretion of cortisol, growth hormone and prolactin in ten healthy young men. After bretazenil we found a significant increase in stage 2 sleep and a significant reduction in stage 3 sleep. REM latency was prolonged. Spectral analysis of sleep-EEG power revealed a decrease in delta and in theta power and an increase in sigma power. We found no significant influence on sleep onset latency or on intermittent wakefulness. Bretazenil prompted a significant decrease in cortisol secretion and a significant increase in prolactin release. It had no major influence on growth hormone secretion.

Key words

Bretazenil Sleep EEG Cortisol Growth hormone Prolactin GABA benzodiazepine receptor EEG power spectra 

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • J. Guldner
    • 1
  • L. Trachsel
    • 1
  • C. Kratschmayr
    • 1
  • B. Rothe
    • 1
  • F. Holsboer
    • 1
  • A. Steiger
    • 1
  1. 1.Max Planck Institute of PsychiatryClinical Institute, Department of PsychiatryMunichGermany

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