, Volume 121, Issue 3, pp 317–322

Differential effects of the D1-DA receptor antagonist SCH39166 on positive and negative symptoms of schizophrenia


  • J. A. Den Boer
    • Department of PsychiatryUniversity Hospital
  • H. J. G. M. van Megen
    • Department of PsychiatryUniversity Hospital
  • B. R. Slaap
    • Department of PsychiatryUniversity Hospital
  • H. G. M. Westenberg
    • Department of PsychiatryUniversity Hospital
  • W. W. Fleischhacker
    • Department of Biological Psychiatry
  • J. W. Louwerens
    • Department of PsychiatryAcademic Hospital Groningen
  • G. D. Burrows
    • Department of PsychiatryUniversity of Melbourne, Austin Hospital
  • O. N. Srivastava
    • Psychiatric Center Rosenburg
Original Investigation

DOI: 10.1007/BF02246069

Cite this article as:
Den Boer, J.A., van Megen, H.J.G.M., Slaap, B.R. et al. Psychopharmacology (1995) 121: 317. doi:10.1007/BF02246069


In the present open study the effects of the D1-dopamine antagonist SCH 39166 on positive and negative symptoms of schizophrenia (DSM-IIIR) were investigated. SCH 39166 was given orally according to a fixed dosage schedule (day 1: 25 mg b.i.d; day 4: 50 mg b.i.d.; day 7: 100 mg b.i.d; day 18: 200 mg b.i.d.; day 21: 225 mg b.i.d.). Seven patients completed 2 weeks, and five patients completed the study. The reason for premature withdrawal was lack of efficacy or refusal to take SCH 39166. In none of the patients a reduction of the BPRS or CGI score was found. As measured with the PANSS, a significant reduction was observed in the score of the negative subscale, whereas the positive symptoms scale and general psychopathology score remained unaffected. Akathisia, rigidity and hypokinesia were reported occasionally, although only mild in severity. The results of the present study do not support the hypothesis that D1-dopamine antagonists are clinically effective antipsychotics in schizophrenia, considering the fact that SCH 39166 had no effect on positive symptoms. The present study provides circumstantial evidence for an effect of SCH 39166 on negative symptoms.

Key words

SchizophreniaD1-dopamine antagonistsSCH 39166AntipsychoticNegative symptoms

Copyright information

© Springer-Verlag 1995