Psychopharmacology

, Volume 104, Issue 4, pp 470–474

Effect on smoking cessation of silver acetate, nicotine and ordinary chewing gum

Influence of smoking history
  • E. J. Jensen
  • E. Schmidt
  • B. Pedersen
  • R. Dahl
Original Investigations

DOI: 10.1007/BF02245651

Cite this article as:
Jensen, E.J., Schmidt, E., Pedersen, B. et al. Psychopharmacology (1991) 104: 470. doi:10.1007/BF02245651

Abstract

In a randomized smoking cessation study 211, 203 and 82 persons were supported with nicotine, silver acetate and ordinary chewing gum, respectively. After 26 weeks there was no overall difference in number of abstainers between treatments. Participants were divided into subsets with low and high weighted packyears consumption (WPY) which modifies tobacco consumption by nicotine content. Abstainer rates in the total population controlled for treatment decreased with increasing WPY (P<0.005). In participants with low WPY abstainer rate was higher in the silver acetate group compared to the nicotine (P<0.0005) and ordinary (P<0.05) chewing gum groups. Nicotine chewing gum was more effective than silver acetate (P<0.05) and ordinary (P<0.05) chewing gum in smokers with high WPY. Ratings on some inconveniences experienced during earlier attempts to quit smoking influenced the ability to break the habit but had no influence on chewing gum effects. This study indicated that through consideration of smoking history it should be possible to individualize pharmacological support to smokers wanting to quit, with silver acetate chewing gum most effective for smokers with a low WPY and nicotine chewing gum most effective for smokers with a high WPY.

Key words

SmokingSilver acetateNicotineChewing gum

Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • E. J. Jensen
    • 1
  • E. Schmidt
    • 1
  • B. Pedersen
    • 1
  • R. Dahl
    • 1
  1. 1.Department of Respiratory MedicineUniversity Hospital, NoerrebrogadeAarhus CDenmark