Psychopharmacology

, Volume 124, Issue 1, pp 201–204

Does eosinophilia predict clozapine induced neutropenia?

  • M. Hummer
  • B. Sperner-Unterweger
  • M. Kurz
  • W. W. Fleischhacker
  • M. Falk
  • G. Kemmler
  • H. Oberbauer
Original Investigation

DOI: 10.1007/BF02245622

Cite this article as:
Hummer, M., Sperner-Unterweger, B., Kurz, M. et al. Psychopharmacology (1996) 124: 201. doi:10.1007/BF02245622

Abstract

The atypical antipsychotic clozapine carries a high risk of inducing agranulocytosis. We attempted to investigate whether eosinophilia during clozapine treatment has predictive value for subsequent neutropenia/agranulocytosis. One hundred and seventy-seven patients were studied in a prospective naturalistic design using haloperidol as the reference compound. Clozapine was found to differ from haloperidol in respect to their influence on neutrophil granulocytes. In the clozapine group patients with eosinophilia showed a decrease in neutrophil count (less than 2000/mm3 neutrophil granulocytes) significantly more often than patients without eosinophilia.

Key words

ClozapineHaloperidolEosinophiliaNeutropeniaAgranulocytosis

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • M. Hummer
    • 1
  • B. Sperner-Unterweger
    • 1
  • M. Kurz
    • 1
  • W. W. Fleischhacker
    • 1
  • M. Falk
    • 2
  • G. Kemmler
    • 3
  • H. Oberbauer
    • 3
  1. 1.Department of Biological PsychiatryInnsbruck University ClinicsInnsbruckAustria
  2. 2.Department of BiostatiticsInnsbruck UniversityA-InnsbruckAustria
  3. 3.Department of General PsychiatryInnsbruck University ClinicsInnsbruckAustria