Psychopharmacology

, Volume 108, Issue 1, pp 210–212

Age-related changes in serotonin 5HT2 receptors on human blood platelets

  • Anat Biegon
  • Nachman Greuner
Original Investigations

DOI: 10.1007/BF02245309

Cite this article as:
Biegon, A. & Greuner, N. Psychopharmacology (1992) 108: 210. doi:10.1007/BF02245309

Abstract

Serotonin receptors of the 5HT2 type were labeled on platelet membranes using tritiated ketanserine. Blood was collected from the umbilical cord of newborns and venous samples were collected from 6-year-old children as well as junior-high and high school students (ages 13 through 18) to determine age-related changes in receptor binding. Among the ages sampled, the highest levels of 5HT2 receptor binding were found in 6-year-olds. A sharp decline in receptor binding occured during adolescence, with levels reduced by half between ages 13 and 17. This pattern is similar to the one we have observed in brain 5HT2 receptors postmortem. There were no significant sex differences in 5HT2 receptors on platelets in newborn and young children. A trend towards higher binding in girls appears around the onset of menstruation in teenage girls (age 14 and up). These results demonstrate that platelet 5HT2 receptors can serve as a model for age dependent changes in 5HT2 receptors in the brain.

Key words

Serotonin receptorsKetanserinePlatelet

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • Anat Biegon
    • 1
  • Nachman Greuner
    • 2
  1. 1.Lawrence Berkeley LaboratoryUniversity of CaliforniaBerkeleyUSA
  2. 2.Department of Biochemistry and the Biochemical Research UnitCarmel HospitalHaifaIsrael