Psychopharmacology

, Volume 113, Issue 3, pp 322–327

Serotonin-induced platelet intracellular calcium mobilization in depressed patients

  • Ichiro Kusumi
  • Tsukasa Koyama
  • Itaru Yamashita
Original Investigations

DOI: 10.1007/BF02245204

Cite this article as:
Kusumi, I., Koyama, T. & Yamashita, I. Psychopharmacology (1994) 113: 322. doi:10.1007/BF02245204

Abstract

Serotonin(5-HT)-stimulated intracellular calcium(Ca) mobilization was measured in the platelets of depressed patients to assess 5-HT2 receptor function. The 5-HT-induced Ca response was significantly higher in unmedicated patients with bipolar depression and melancholic major depression than in those with non-melancholic major depression and normal controls. The enhanced Ca response to 5-HT failed to correlate with severity of depressive symptoms. In patients with bipolar disorder and melancholic major depression, there was no significant difference in 5-HT-stimulated Ca response between the unmedicated group and those in remission. These results suggest that 5-HT2 receptor function is increased in some types of depression, and raise the possibility that the enhanced Ca response to 5-HT may be trait dependent rather than state dependent.

Key words

SerotoninCalciumPlateletDepression

Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • Ichiro Kusumi
    • 1
  • Tsukasa Koyama
    • 1
  • Itaru Yamashita
    • 1
  1. 1.Department of Psychiatry and NeurologyHokkaido University School of MedicineSapporoJapan