Dose-response relationship for oral idazoxan effects in healthy human subjects: comparison with oral yohimbine
- Cite this article as:
- Krystal, J.H., McDougle, C.J., Woods, S.W. et al. Psychopharmacology (1992) 108: 313. doi:10.1007/BF02245117
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The effects of oral administration of the α2 adrenergic receptor antagonists idazoxan (20 mg, 40 mg, 80 mg) and yohimbine (20 mg) were compared using a placebo-controlled within-subjects design. Healthy subjects completed 5 test days during which medication effects on mood and anxiety states, physiologic indices, plasma cortisol levels, and plasma levels of the norepinephrine metabolite 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) were assessed. Idazoxan dose-dependently increased plasma MHPG, plasma cortisol, systolic and diastolic blood pressure, and Panic Attack Symptom Scale scores in healthy subjects. Overall, yohimbine and idazoxan produced a similar pattern of behavioral and neuroendocrine responses. Since idazoxan possesses relatively greater receptor specificity compared to yohimbine, it may be a more useful α2 antagonist in humans.