Psychopharmacology

, Volume 112, Supplement 1, pp S35–S39

Differential changes in serotonin 5-HT1A and 5-HT2 receptor binding in patients with chronic schizophrenia

Authors

  • Takeshi Hashimoto
    • Department of Psychiatry and NeurologyKobe University School of Medicine
  • Noboru Kitamura
    • Department of Psychiatry and NeurologyKobe University School of Medicine
  • Yasuo Kajimoto
    • Department of PharmacologyKobe University School of Medicine
  • Yutaka Shirai
    • Department of PharmacologyKobe University School of Medicine
  • Osamu Shirakawa
    • Department of Psychiatry and NeurologyKobe University School of Medicine
  • Tatsuo Mita
    • Department of PsychiatrySaiseikai Nakatsu Hospital
  • Naoki Nishino
    • Department of Psychiatry and NeurologyKobe University School of Medicine
  • Chikako Tanaka
    • Department of PharmacologyKobe University School of Medicine
Article

DOI: 10.1007/BF02245005

Cite this article as:
Hashimoto, T., Kitamura, N., Kajimoto, Y. et al. Psychopharmacology (1993) 112: S35. doi:10.1007/BF02245005

Abstract

Serotonin 5-HT1A and 5-HT2 receptors were examined in the postmortem brains of controls and patients with chronic schizophrenia. In the prefrontal cortex from patients with schizophrenia, 5-HT1A receptor binding was increased, while 5-HT2 receptor binding was decreased, when compared to controls. The increased 5-HT1A receptor binding or the decreased 5-HT2 receptor binding was observed in both the patients who had been medicated with neuroleptics at time of death and those who had not, at least 2 months prior to death. Thus, abnormalities of 5-HT receptor subtypes seem to exist in the brains of patients with chronic schizophrenia. 5-HT related agents might be beneficial for the treatment of schizophrenia.

Key words

SerotoninSerotonin1A(5-HT1A) receptorSerotonin2(5-HT2) receptorSchizophreniaPostmortem brain

Copyright information

© Springer-Verlag 1993