Rapid Communication

Psychopharmacology

, Volume 114, Issue 4, pp 672-674

The putative anti-addictive drug ibogaine is a competitive inhibitor of [3H]MK-801 binding to the NMDA receptor complex

  • Piotr PopikAffiliated withLaboratory of Neuroscience, NIDDK, National Institutes of Health
  • , Richard T. LayerAffiliated withLaboratory of Neuroscience, NIDDK, National Institutes of Health
  • , Phil SkolnickAffiliated withLaboratory of Neuroscience, NIDDK, National Institutes of Health

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Abstract

Ibogaine is a putative anti-addictive drug with potential efficacy for the treatment of opiate, stimulant, and alcohol abuse. We now report ibogaine is a competitive inhibitor (Ki, 1.01±0.1 µM) of [3H]MK-801 binding toN-methyl-D-aspartate (NMDA) receptor coupled cation channels. Since MK-801 can attenuate the development of tolerance to morphine and alcohol as well as sensitization to stimulants in preclinical studies, the reported ability of ibogaine to modify drug-seeking behavior in man may be attributable to a blockade of NMDA receptor coupled cation channels.

Key words

MK-801 (dizocilpine) Ibogaine NMDA receptors Drug abuse