Psychopharmacology

, Volume 112, Issue 4, pp 461–466

Ritanserin attenuates anorectic, endocrine and thermic responses tod-fenfluramine in human volunteers

Authors

  • E. M. Goodall
    • Department of Psychological MedicineMedical College of St. Bartholomew's Hospital
  • P. J. Cowen
    • MRC Unit of Clinical Pharmacology and University Department of PsychiatryLittlemore Hospital
  • M. Franklin
    • MRC Unit of Clinical Pharmacology and University Department of PsychiatryLittlemore Hospital
  • T. Silverstone
    • Department of Psychological MedicineMedical College of St. Bartholomew's Hospital
Original Investigations

DOI: 10.1007/BF02244895

Cite this article as:
Goodall, E.M., Cowen, P.J., Franklin, M. et al. Psychopharmacology (1993) 112: 461. doi:10.1007/BF02244895

Abstract

This study investigated the role of the 5-HT2/1C receptor antagonist ritanserin ond-fenfluramine (d-FF) induced changes in food intake, prolactin (PRL) secretion and oral temperature in 12 healthy male volunteers. The study was double blind and placebo controlled. Food intake was measured using an automated food dispenser.d-FF (30 mg) significantly reduced fat intake. While ritanserin (5 mg) had no effect when given alone it abolished thed-FF induced reduction in fat intake. In addition, ritanserin abolished thed-FF induced rise in PRL and oral temperature. The results suggest that 5-HT2 or 5-HT1C receptors mediate the effects ofd-fenfluramine on appetite, prolactin secretion and temperature in humans.

Key words

d-FenfluramineRitanserinFood intakeProlactinBody temperatureHuman volunteers
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Copyright information

© Springer-Verlag 1993