Original Investigations

Psychopharmacology

, Volume 106, Issue 4, pp 459-462

First online:

Lack of effect of high-dose cocaine on monoamine uptake sites in rat brain measured by quantitative autoradiography

  • S. BenmansourAffiliated withDepartment of Psychiatry, University of Pennsylvania School of Medicine and Neuropsychopharmacology UnitDepartment of Veterans Affairs Medical Center, University and Woodland Avenues
  • , S. M. Tejani-ButtAffiliated withDepartment of Psychiatry, University of Pennsylvania School of Medicine and Neuropsychopharmacology UnitDepartment of Veterans Affairs Medical Center, University and Woodland Avenues
  • , M. HauptmannAffiliated withDepartment of Psychiatry, University of Pennsylvania School of Medicine and Neuropsychopharmacology UnitDepartment of Veterans Affairs Medical Center, University and Woodland Avenues
  • , D. J. BrunswickAffiliated withDepartment of Psychiatry, University of Pennsylvania School of Medicine and Neuropsychopharmacology UnitDepartment of Veterans Affairs Medical Center, University and Woodland Avenues

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Abstract

There have been a number of claims that high-dose administration of cocaine to rats leads to neurotoxic effects on dopamine neurons. In this study possible neurotoxic effects on monoamine neurons were examined by measuring the effects of cocaine (35 mg/kg daily for 10 days) on the binding of radioligands to uptake sites for dopamine, serotonin and norepinephrine using quatitative autoradiography. No effects of cocaine on any of the binding sites were observed and therefore, it is concluded that cocaine, unlike amphetamine derivatives which have similar pharmacologic properties, does not produce neurotoxic effects on monoamine neurons.

Key words

Neurotoxicity Cocaine Dopamine Serotonin Norepinephrine Uptake sites